TMS bij depressie, een onderzoek
A 14 WEEK EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN DEPRESSION:
A RANDOMIZED PLACEBO CONTROLLED TRIAL
Running title: rTMS reduces major depression up to 14 weeks
Eindwerkstuk ingediend ter verkrijging van het Benelux Diploma
VOORTGEZETTE OPLEIDING COUNSELING EN COACHING
Door: Drs M.C.J.A. Bär-van Broekhoven
Academiejaar 2004-2005
BeNeLux-Universitair Centrum
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Begeleid door: |
prof. dr. A. van der Geld |
Antwerpen / Eindhoven / Luxemburg 2004
Benelux Merkenwet (BMW) registratienummer 535508
A 14 WEEK EFFECT OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN DEPRESSION:
A RANDOMIZED PLACEBO CONTROLLED TRIAL
M.C.J.A. Bär, M.A.M. Willems, D.M. Laman, H. van Duijn, I.L. Tensen, M.A.J. van Duijn, G.F. Koerselman
M.C.J.A. Bär, Research Psychologist, Department of Psychiatry, St Lucas Andreas Hospital, Amsterdam, The Netherlands
M.A.M. Willems, Psychiatrist, Department of Psychiatry, St Lucas Andreas Hospital, Amsterdam, The Netherlands
D.M. Laman, Neurophysiologist, Department of Neurophysiology, St Lucas Andreas Hospital, Amsterdam, The Netherlands
H. van Duijn, Doctor of Neurophysiology, Department of Neurophysiology, St Lucas Andreas Hospital, Amsterdam, The Netherlands
I. L. Tensen Doctor in Medicine, Department of Psychiatry, St Lucas Andreas Hospital, Amsterdam, The Netherlands
M.A.J. van Duijn, Associate Professor, Department of Statistics and Measurement Theory, University of Groningen, The Netherlands
G.F. Koerselman, Professor Doctor of Psychiatry, Department of Psychiatry, St Lucas Andreas Hospital, Amsterdam, The Netherlands, University of Utrecht, The Netherlands.
Address for correspondence M.C.J.A. Bär.
Background/Objective:
Although there is evidence for an antidepressant effect of Repetitive Transcranial Magnetic Stimulation (rTMS) little is known about long term effect. We conducted a placebo-controlled double-blind study in depressed patients to investigate the effect on depression over a period of 14 weeks.
Methods:
57 patients with a moderate or severe major depressive episode were randomly assigned to rTMS or sham treatment. rTMS was given daily for ten days with the following treatment parameters: 20Hz, 20 trains of 2 seconds and 80% motor threshold over the left dorsolateral prefrontal cortex (DLPFC). The effect on depression was rated at several moments during the 14-week period.
Results:
A continuous decrease in depression was seen during the whole follow-up period of 12 weeks in rTMS patients, but in sham patients improvement stopped after the two weeks of treatment had ended.
Conclusions:
We found that rTMS is effective in the treatment of depressive patients. As improvement increased with time in the 12 weeks after treatment, rTMS proved to be of clinical utility.
Key words:
depression, transcranial magnetic stimulation, left dorsolateral prefrontal cortex, 12-week follow-up period.
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